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August 08.2025

2 Minutes Read

Discover How Molecular Imaging Tech Measures Forces in Living Cells

Molecular imaging technology showcased in complex data layout with vivid imaging slices.

Revolutionizing Our Understanding of Molecular Forces

Researchers at the University of British Columbia (UBC) Okanagan are on the cusp of a groundbreaking advancement in the field of molecular imaging technology. Their innovative approach combines DNA-based molecular tension probes with advanced microscopy techniques to measure molecular forces in living cells with unprecedented precision. This technology, known as quantitative PAINT (qtPAINT), allows scientists to see not just where molecular forces are acting, but also measure their strength and variability over time.

Why This Technology Matters

Molecular forces play an essential role in various biological functions, from fighting infections to wound healing and even cancer progression. Dr. Seongho Kim, lead author of the study, emphasizes the need for such precision: "Before qtPAINT, our understanding was limited to mere observation." This advancement opens doors for scientists to closely examine how these microscopic forces work in real-time, giving us a clearer picture of cellular behavior.

Combatting Biological Challenges

In addition to qtPAINT, the research team tackled another critical challenge: the rapid degradation of DNA-based tension probes caused by natural enzymes known as DNases. Their solution involves the clever use of "decoy DNA," which acts as a sacrificial target to protect the functional probes. Lead author Hongyuan Zhang describes this approach as a way to “distract predators”—effectively extending the lifespan of these crucial tools from hours to several days.

Implications for the Future of Biology

This leap in technology promises significant implications for the fields of biology and biotech. With greater stability and accuracy in measuring cellular forces, scientists could potentially understand the mechanics behind numerous physiological processes, leading to improved treatment options for various diseases.

What’s Next for qtPAINT?

Looking ahead, the innovative pair of technologies—qtPAINT and decoy DNA—may not just revolutionize our understanding of cells but could also inspire novel methods to investigate other complex systems in biology. Such advancements could lend insights that improve how we approach health challenges today.

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Discover How Molecular Imaging Tech Measures Forces in Living Cells

Revolutionizing Our Understanding of Molecular Forces

Why This Technology Matters

Combatting Biological Challenges

Implications for the Future of Biology

What’s Next for qtPAINT?

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